If you’re talking about a browser, Firefox I believe can config custom DNS, but idk about it working alongside the extension if the extension needs to use its own. For the browser, I use PrivacyBadger from EFF for cookie and tracker blocking and PortAuthority which blocks LexisNexis port scanning on sites like eBay, etc. My adblock is done through pihole. Pihole uses Quad9 for the resolver.